About ISB

In Silico Biology

Journal of Biological Systems Modeling and Simulation

ISSN 1386-6338 (Print)
1434-3207 (Online)
Volume 12; 6 issues
Status Last issue 12(1,2) online on 07 July 2015
Next issue 12(3) scheduled for April 2016
Back volumes 1-10
Subject Group Biochemistry, Medicine & Health

In Silico Biology 
is a scientific research journal aiming to advance the use of computational models and simulations in studies of complex biological phenomena. We publish peer-reviewed leading-edge biological, biomedical and biotechnological research in which computer-based (i.e., “in silico”) modeling and analysis tools are developed or applied to generate new knowledge about biological systems dynamics, design and control.

Abstracted/Indexed In

  • Academic Source Complete
  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts Service
  • Chemical Abstracts Service (CAS)
  • EBSCO database
  • Elsevier BIOBASE
  • Embase
  • Inspec IET
  • Pubmed
  • Scopus
  • Ulrich’s Periodicals Directory


For subscription information, click here.


ISB’s targeted audience is comprised of users of the application of theoretical, mathematical and computational tools onto biological systems.

The Publisher

For over 25 years IOS Press has been serving the scientific community worldwide. IOS Press publishes approximately 120 new books each year and around 100 international journals, covering topics ranging from computer science and mathematics to medicine and the natural sciences.
All titles are available online as well as in print. Many titles are listed in the most important abstracting databases, such as Thomson Reuters, MEDLINE and Scopus.
Headquartered in Amsterdam with satellite offices in the USA, Germany, India and China, IOS Press has established several strategic co-publishing initiatives. Notable acquisitions included Delft University Press in 2005 and Millpress Science Publishers in 2008.
IOS Press journals are available through our IOS Press Content Library. We offer our complete ejournals collection of journals at a deep discount.

Open Access

IOS Press is committed to support the computational biology community and will provide free open access to all published papers that were submitted for review prior to Dec 31, 2017. A fee may be applied for open access after that date (the current fee is €900 or US$1250).







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Aims & Scope

In Silico Biology 
is a scientific research journal for the advancement of computational models and simulations in studies of complex biological phenomena. We publish peer-reviewed leading-edge biological, biomedical and biotechnological research in which computer-based (i.e., “in silico“) modeling and analysis tools are developed and applied to generate new knowledge about biological systems dynamics, their design and control, and their evolution.

Studies published in In Silico Biology generally use theoretical models and computational analysis to gain quantitative insights into regulatory processes and networks, cell physiology and morphology, tissue dynamics and organ systems. Specific areas of interest include signal transduction and information processing, gene expression and gene regulatory networks, metabolism, differentiation and morphogenesis, among others.

In Silico Biology also publishes foundational research in which novel algorithms are developed to facilitate modeling and simulations. Such research must demonstrate application to a concrete biological problem.

In Silico Biology frequently publishes special issues on seminal topics and trends. Special issues are handled by Special Issue Editors appointed by the Editor-in-Chief. Proposals for special issues should be sent to the Editor-in-Chief.

About In Silico Biology

The term “in silico” is a pendant to “in vivo” (in the living system) and “in vitro” (in the test tube) biological experiments, and implies the gain of insights by computer-based simulations and model analyses.

In Silico Biology (ISB) was founded in 1998 as a purely online journal. IOS Press became the publisher of the printed journal shortly after. Today, ISB is dedicated exclusively to biological systems modeling and simulations and is published solely by IOS Press. The previous online publisher, Bioinformation Systems, maintains a website containing studies published between 1998 and 2010 for archival purposes.

We strongly support open communications and encourage researchers to share results and preliminary data with the community. Therefore, results and preliminary data made public through conference presentations, conference proceeding or posting of unrefereed manuscripts on preprint servers will not prohibit publication in ISB. However, authors are required to modify a preprint to include the journal reference (including DOI), and a link to the published article on the ISB website upon publication.

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Editorial Board


Matteo Barberis, Ph.D.
Assistant Professor
University of Amsterdam
Swammerdam Institute for Life Sciences
Science Park 904
1098 XH Amsterdam
The Netherlands
Email: M.Barberis@uva.nl

Mads Kaern, Ph.D.
Associate Professor
Ottawa Institute of Systems Biology
Department of Cellular and Molecular Medicine
University of Ottawa
451 Smyth Road
Ottawa, Ontario K1H 8M5
Email: isb@iospress.com

Advisory Board
Dennis Bray
University of Cambridge, UK

Roland Eils
University of Heidelberg, Germany

Albert Goldbeter
Université Libre de Bruxelles, Belgium

Hiroaki Kitano
The Systems Biology Institute, Japan

Michael Mackey
McGill University, Canada

John Tyson
Virginia Tech, USA

Hans Westerhoff
University of Manchester, UK

Former Editors-in-Chief

Edgar Wingender

Jack Leunissen †
The Netherlands

Editorial Board
John Aitchison,
Institute for Systems Biology, USA

Ilya Akberdin
Institute of Cytology and Genetics, Russia

Gabor Balazsi
University of Texas, Houston, USA

Diego di Bernardo
Telethon Institute for Genetics and Medicine, Italy

Daniel Charlebois
Stony Brook University, USA

Sangdun Choi
Ajou University, Korea

Daniel Coombs
University of British Columbia, Canada

Eldon Emberly
Simon Fraser University, Canada

Brian Ingalls
University of Waterloo, Canada

Johannes Jaeger
Centre for Genomic Regulation, Spain

Yves Lussier
University of Chicago, USA

Ion Mandoiu
University of Connecticut, USA

William Mather
Virginia Tech, USA

Nicolas Mermod
University of Lausanne, Switzerland

David Gómez Míguez
Universidad Autónoma de Madrid, Spain

Theodore Perkins
Ottawa Hospital Research Institute, Canada

Andre Ribeiro
Tampere University of Technology, Finland

Moises Santillan
Centre for Research and Advanced Studies, Mexico

Kumar Selvarajoo
Keio University, Japan

Narayanaswamy Srinivasan
Indian Institute of Science, India

Peter Swain
University of Edinburgh, Scotland, UK

Jose Vilar
University of the Basque Country, Spain

Xiao Wang
Arizona State University, USA

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